It's significant if the key words used to find your site matches your domain name. Some search engines may rank your site site slightly higher if the keywords entered in the actual search for your site match your domain name. For example, if people who looked for your site often used the term 'Los Angeles Real Estate' and you owned losangelesrealestate.com and your site was about real estate, there is a good chance that your site would come up as a top ranked within the search results. However, in general, it's always a good idea to secure a domain name relevant to real estate, your business, your type of clients, your area or your name. Stick to keywords you think will be most often used to find yoursite. You can also try using the words "real estate" and/or "homes" (i.e. MidCityRealEstate.com or Bevelywoodhomes.com) in the mix when you register your domain name.